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Our research group has conducted a recent assessment of the progress made in investigating the relationship that has been extensively studied in the brain using rodent models in recent years (144)

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Over the 8 residues spanning P4 to P4, it has 7 of 8 identical to the M pro site at the nsp12/nsp13 junction, with the only mismatch at the highly variable P3 position (Figure 1D), giving a near-perfect match to the M pro consensus

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It is used in the treatment of neurological conditions caused due to vitamin B1, vitamin B6 and vitamin B12 deficiency