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treated people suffering from severe B12 malabsorption with 2,000 g of cyanocobalamin per day (Kuzminski, 1998)

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Lancet 329(8526):183188 Vendelboe TV, Harris P, Zhao Y, Walter TS, Harlos K, El Omari K, Christensen HE (2016) The crystal structure of human dopamine -hydroxylase at 2.9 resolution

While the specific amount needed varies by individual and climate, most adults benefit from drinking approximately two liters of fluids daily, adjusting for activity level and environmental conditions