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Platelet lysates stimulate angiogenesis, neurogenesis and neuroprotection after stroke

Molecular dynamics is widely used in the analysis of conformational changes in the pockets of target proteins 44 , as well as in the design and research of inhibitors based on the structure of the target 45,46

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It is worth noting that the derivation of HBGVs applies extrapolation factors (also termed safety factors) to account for toxicodynamic and toxicokinetic differences between species and inter-individual variability in humans

These prodrugs which are fine-tuned the activation kinetics may further promote their therapeutic efficacy and reduce the off-target side effects