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Interestingly, preconception administration of liraglutide 1.2 mg and metformin was associated with increased pregnancy rate per embryo transfer and cumulative pregnancy rate in women with obesity in PCOS compared to metformin monotherapy, despite similar weight reduction 98

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Semaglutide's mechanism of action is so potent that the FDA approved it specifically for weight management, backed by large randomized controlled trials demonstrating sustained weight loss

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A randomized, open, controlled trial of tretinoin 0.05% cream vs