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Folic acid, which is the form found in fortified foods and supplements is also a poor substrate for folylpolyglutamate synthase accounting for its efficient uptake from the intestines and release to the blood

Current trial status and protocol details can be verified via ClinicalTrials.gov , the EU Clinical Trials Information System (CTIS) , or the ISRCTN registry

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Therefore, whether the occurrence of a pro-oxidant state caused by an altered intracellular redox status, which might increase homocysteinylation, is one of the molecular bases of the potential atherogenicity of moderate hyperhomocysteinemia remains to be determined

These results highlight the need for clinical trials to determine effective dosing, treatment duration, combination strategies, and long-term safety

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