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Conservative treatment is the first-line approach, but if physiotherapy fails, there is no consensus in the literature on further therapy
DNA methylation and gametogenesis are intricately linked due to the fact that primordial germ cells are profoundly demethylated and subsequently re-methylated during a later developmental period: prenatal life in males and postnatal development in females
Note: only two species of Nori contain bioavailable B12: dried green laver ( Enteromorpha sp.) and purple laver ( Porphyra sp.) A 2014 article, on vegetarian nutrition, notes that most other forms of algae have only trace amounts, if any, B12: Dried green laver (Enteromorphasp.) and purple laver (Porphyra sp.) are the most widely consumed edible algae, and they contain substantial amounts of Vitamin B12 (approximately 63.6 g/100 g dry weight and 32.3 g/100 g dry weight, respectively)
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