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Ocular signs included epicanthal folds, palpebral ptosis, sunken eyes, infraorbital creases, hypotelorism, hypertelorism/telecanthus, myopia, strabismus, xeropthalmia, and elongated/up-slanting palpebral fissures (Fig

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As another indicator of FDAs intentions, the agencys guidance on nonclinical testing of inhaled nicotine drug products provides some insight into the requirements for sponsors seeking to market ENDS as drugs: toxicology testing and submission of information on components of the product, inhalation studies, assessment of product impurities, etc

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