GSH directly neutralizes reactive oxygen species (ROS), including hydrogen peroxide (HO) and lipid peroxides, and contributes to the detoxification of xenobiotics and electrophilic compounds through conjugation reactions mediated by glutathione S-transferases (GSTs) [36]
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Specifically, it was revealed that MnO 2 within the composite exhibits enzyme-like catalytic functions, capable of both reducing intracellular GSH levels and promoting H 2 O 2 decomposition to produce O 2 ( Figure 4E )
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Additionally, we found that sodium pyruvate, and L -methionine had little effect on the number of lesions observed, suggesting peroxide and hypochlorous acid are not involved in the DNA damage mechanism of Cu 3 -TC-Py
A 2024 randomised trial found IV glutathione reduced melanin by 18.7% over eight weeks, while oral glutathione at higher cumulative doses reduced melanin by only 3.2%