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International journal of preventive medicine

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Fuel Depletion

The allopurinol metabolite, oxypurinol, drives oligoclonal expansions of drug-reactive T cells in resolved hypersensitivity cases and drug-nave healthy donors

10.1073/pnas.1316569111 Summary Keywords TMA, TMAU, TMAO, CVD, postbiotic, rare disease, tyndallized Citation Giannini G, Soldi S, Elli M, Sagheddu V, Castagnetti A, Viciani E, Salvini L, Battistuzzi G, Milazzo FM, Alibrandi S and Sidoti A (2025) A mixture of postbiotics/tyndallized probiotics reduces trimethylamine (TMA) in trimethylaminuria models: Evidence from in vitro and in vivo studies

The advantage over direct GH is that secretagogues preserve natural pulsatile GH release patterns and work within physiological regulatory constraints