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Researchers have also studied this mechanism in relation to muscle-tissue models and general markers of cellular aging

An evidence-based review of fat modifying supplemental weight loss products

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Patients who have undergone gastric bypass or other bariatric procedures have surgically altered anatomy that reduces the absorptive surface area in the stomach and small intestine

In other words, the preclinical signal appears against a backdrop of controlled energy intake and activity, not as a standalone effect that overrides diet