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Cancer J (Sudbury, Mass.) 20(3):170 Hwang JS, Hwang JS, Chang I, Kim S (2007) Age-associated decrease in proteasome content and activities in human dermal fibroblasts: restoration of normal level of proteasome subunits reduces aging markers in fibroblasts from elderly persons

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thus, it readily reacts with the SH group of G-site bound GSH to form a disulfide linkage 22,23