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Development of nano-formulation containing rutin for the protective and beneficial effect against 6-hydroxydopamine induced Parkinsons disease model via altered the genetic backgrounds

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In the control group, there was no cartilage tissue formation due to the limited regeneration capability of the native cartilage tissue

By defining global and gene-specific DNA 5hmC modifications, we demonstrated that DMF induces 5hmC modifications to influence loci-specific chromatin structure through L2HGDH to reduce the levels of L2HG