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This created a hypoxic environment where the nadir O 2 chamber reached 4.5 1.5% for 7 to 10 s and was immediately followed by an air break (21% O 2

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452 Endothelial cells exhibit enhanced NO production and concurrent suppression of endothelin formation, resulting in vascular smooth muscle relaxation and vasodilation mediated by the endothelium (e.g., GLP-1, exenatide, and liraglutide)