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Rodent dosing at 1 to 10 micrograms per kilogram does not translate directly to humans
Research-Chemical-Anbieter ohne Drittlabortest-Verifikation produzieren Substanzen variabler Reinheit, potenzieller bakterieller Kontamination und ungenauer Wirkstoff-Konzentration
10.1371/journal.pone.0223302 [DOI] [PMC free article] [PubMed] [Google Scholar] 56.Ohnaka K, Kono S, Inoguchi T, Yin G, Morita M, Adachi M, et al
Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug
10.1093/nar/gkl869 Nucleic Acids Res