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The transporter structure is vital for understanding its interaction with drugs, making the study of its 3D structure as important as its clinical relevance at a functional level

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doi:10.3390/ijms19071987 Wang X, Liu B, Xu Q, et al

10.1016/j.bbrc.2009.07.003 69 HernndezJ

Lack of absorption and genetic factors may also contribute to vitamin B12 deficiency

lowest tolerated dose Phase Step 2 Weeks Weeks 5-8 Cagrilintide Dose 0.5 mg/week Purpose Dose escalation Phase Step 3 Weeks Weeks 9-12 Cagrilintide Dose 1.0 mg/week Purpose GI side effects often peak here Phase Step 4 Weeks Weeks 13-16 Cagrilintide Dose 1.7 mg/week Purpose Approaching maintenance Phase Maintenance Weeks Weeks 17+ Cagrilintide Dose 2.4 mg/week Purpose Target dose used in late-stage study protocols Each step lasts 4 weeks