Doctor Castori insists on the notion of pleiotropy (a single gene influences multiple phenotypic traits) and recalls that hypermobility naturally decreases with age: the Beighton score tends to fall below 5 at the mean age of 33 years (which is the recommended cut-off value for diagnosis)

[ref] Not only is B6 important in dopamine production, but it is also important in the creation of glutathione (an antioxidant) in the brain.[ref] Parkinsons patients on L-DOPA also often have low or deficient B6 levels.[ref] Related article : Parkinsons disease and genetic susceptibility Chronic inflammation: Inflammatory conditions, including rheumatoid arthritis, IBD, diabetes, cancer, and deep vein thrombosis, are all associated with low vitamin B6 levels.[ref] While inflammatory conditions are linked to low vitamin B6 levels, it may be (at least partly) because systemic inflammation decreases the bodys P5P levels, and dietary intake isnt sufficient to meet the increased need.[ref] Related article: Chronic inflammation and personalized solutions Asthma and COPD: A recent study showed that higher vitamin B6 intake correlates with higher FEV1 levels (lung function test) in CoPD
5-HIAA, 5-hydroxyindoleacetic acid
Each analysis done with DESeq2 used a two-sided Wald test
J Neurosci Off J Soc Neurosci 32:92489264
They act on different systems