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However, the amount of curcumin consumed through food is limited, and absorption is further hindered by the poor bioavailability of curcumin in its natural form

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A structure-based assignment of the glutathione activator site without transition-state analogues is much more difficult because of labile GSH interactions 2 that likely depend not only on the presence of the first glutathione moiety but also on conformational changes of the glutathionylated enzyme 3,12,37,44

Compared with bacterial CGS, plant CGS have an N-terminal extension (amino acids 77-87) that displays a regulatory role (Hacham et al., 2002)