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As the disease progresses, the abnormal synovium invades surrounding tissues, and produces chemical substances that destroy the cartilage and bone of the joint surface

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Experimental observations indicate that the combination allows investigation of complementary pathways in tissue regeneration, including vascular growth, fibroblast recruitment, matrix reorganization, and oxidative stress responses

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On the other hand, PDA is collagen-focused a top choice for wound healing and tissue regeneration