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Han L, Zhang Q, Shi C, Cavazos A, Ruvolo VR, Leverson JD, Dail M, PhillipsDC, Chen J, Jin SS, Jacamo R, Daver N, Jabbour E, Kantarjian HM, Andreeff M , SampathD, Konopleva M

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Sci, 23 (2022): p.6460

Constipation, which involves infrequent or difficult bowel movements, can cause cramping and discomfort after a night without bowel activity