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Prevalence of Novel Tobacco Products (NTPs) The use of traditional cigarettes has declined rapidly in the last few decades in the US [17, 29], in part due to their documented deleterious health effects [30]

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The cellular furin levels were reduced by smoking [331], whilst TMPRSS4 and TMPRSS2 increased and unchanged in bronchial epithelial cells from current smokers in comparison with never smokers [330]

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