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The resultant increases in heart rate, blood pressure, contractility and peripheral vascular resistance imbalances the myocardial oxygen supplydemand ratio which makes the heart vulnerable for ischaemic damage.[10] Respiratory system The irritants and ciliotoxins present in tobacco smoke increases mucous production and weakens the mucus clearance mechanism in the tracheobronchial tree.[11] This leads to clogging of the lungs with hyperviscous thick mucus secretion, bacteria and dead cells making lungs vulnerable to various infections.[12] An increase in proteolytic and elastolytic enzymes leads to loss of elasticity and emphysema