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The researchers found that the immune cells of these patients are subjected to extreme levels of reactive oxygen species, leading to severe mitochondrial damage and a catastrophic failure of cellular energy production

It comes out that if melatonin has a positive effect on granulosa cells, it decreases androgen production and enhances heme oxygenase-1 expression, which gives a direct reflection of the benefits for oocyte quality and also helps in oxidative stress issues [187]