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Preparation of antibody-targeted particles The chemically modified PEG lipid, DSPE-PEG 2k-maleimide (#880126 P, Merck), was added to the lipid component at 1:3 molar ratio of DSPE-PEG 2k-maleimide to DMG-PEG 2k

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Clinical models are useful for understanding how the BBB is functioning and disrupted in patients with disease, however drugs and therapeutics are not screened in clinical models until there is some certainty using in vivo and models that the therapeutic is safe and effective

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