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It supplies the mechanistic and directional rationale for the whole compound class, but it is not a human trial and does not establish a human dose
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High doses might make optic nerve damage worse
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B12 injections are most clearly indicated when: A person has confirmed B12 deficiency that requires rapid replacement Theres a known or likely absorption issue Theres a need for ongoing maintenance due to non-dietary causes (for example, autoimmune gastritis) Typical treatment schedules (UK guidance) Treatment schedules can vary depending on symptoms, severity, and cause
Dietary considerations The compound does not suppress appetite, so dietary discipline remains necessary for creating the caloric deficit needed for fat loss
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