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(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)

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Ferulic acid alleviates retinal neovascularization by modulating microglia/macrophage polarization through the ROS/NF-B axis

Elevated levels of ROS and iron in haematopoietic cells lacking the H-ferritin gene lead to a reduction in T-cell populations ( Figure 2 ) (112)

Figure 2 Although T-cell/APC conjugate formation can be measured using flow cytometry, this technique is limited for evaluating spatial informations which are important for analysing the formation of the immune synapse

10.3390/biom5042247 Biomolecules