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Withaferin A (WA), a steroidal lactone obtained from Withania somnifera extract, inhibits neuro-apoptosis, modulates vascular smooth muscle cell (VSMC) migration, and activates PI3K/Akt signaling

These effects can be qualified to many mechanisms, mainly anti-inflammation, antioxidative stress, anti-apoptosis, brain blood barrier modulation, inhibition of platelet activation and thrombus formation, and promotion of neurogenesis and angiogenesis, targeting multiple intracellular mediators and signaling pathways, including BDNF/PI3K/Akt/mTOR/CREB/GSK3/NF-B/Nrf2/NOS, where the central role is phosphoryl inositol 3 kinase (PI3K)/protein kinase B (AKT) (Figure 8)

Once reconstitued store at 2-8C (refrigerator)

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Benefits may develop over days to weeks, depending on the context and consistency of use