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In summary, liver enlargement can be the consequence of hepatocellular hypertrophy, hepatocellular hyperplasia, or both in response to enzyme induction

Thinning hair and reduced density

It acts as a cofactor for methionine synthase, which is required for the production of SAMe, the methyl donor involved in synthesis of serotonin and dopamine

For the single-cell RNA sequencing analyses, healthy controls were derived from publicly available external datasets rather than controls processed in parallel with our patient samples, which may introduce batch effects

Consideration in the design of effective nano herbal formulation of novel phytoconstituents comprises understanding the cell signaling pathway in the origin and progress of CKD, followed by its inhibition in altering the disease condition (inflammation, oxidative stress, and fibrosis)