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There is general agreement that M3 receptors are primarily responsible for the normal contraction of the urinary bladder, although M2 receptors are also present, and my act to oppose sympathetically mediated smooth muscle relaxation mediated by beta-3 receptors (Andersson & Arner, 2004)

Dysfunction of SLC7A11 has been reported in diverse types of cancer, including PC, and is closely related to the malignant behavior of cancer [31, 32]