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B.MeloniM.GraianiG.PaniE.CristofaroB.et al (2008)

Astrocytes with low GSH may become less protective over time, releasing more inflammatory mediators and failing to supply an adequate amount of GSH and GSH precursors to neighboring neurons and microglia (Kwon et al., 2019

Glutathione is foundational for good health

10.3390/ijms22073574 112 KanazawaL

doi: 112

this created a crucial need to understand the mechanism of these types of resistance, this understanding can help developing strategies to overcome tamoxifen resistance