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These modern nicotine sales are making up 50% of our loss in sales from the decline in cigarettes. The retailer, a subsidiary of Tokyo-based Seven & i Holdings Co., said it is also looking to cut costs and to become more efficient as it targets a 90-basis-point reduction in operating, selling, general and administrative costs as a percentage of sales this year

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A limitation was the brief follow-up and the inclusion of youth with a history of smoking, which treated ever smoking as a covariate and baseline current smoking frequency as a moderator rather than eliminating baseline ever-smokers from the analysis to prevent reverse causation

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