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In addition to the up-regulation of cytoskeletal proteins in platelets from -thalassemia/HbE patients, we observed the up-regulation of integrin, a transmembrane receptor protein that acts as a bridge between the extracellular matrix and the cytoskeletal membrane that mediates signal transduction in activated platelets, resulting in platelet shape changes and platelet aggregation 22

doi: 10.1016/S0140-6736(09)60619-X

Toll-like receptor misrecognition is considered to be an important step in alpha-synucleinopathy progression, and increased intestinal permeability, immune activation, and enteric neuroglial activation are keys in the pathophysiology of Parkinsons disease (158)

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doi: 10.1096/fj.05-4985fje

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