In the same work, cystine availability was lower in autochthonous PDAC tumours compared with subcutaneous tumours, supporting the relevance of anatomical location for the metabolic microenvironment
Nonetheless, these mice harbored activated mucosal immune components as demonstrated by increased numbers of lamina propria CD4(+)lymphocytes, redistribution of CD11c(+)cells, increased production of the proinflammatory cytokines interferon- and tumor necrosis factor- (TNF-), and expression of epithelial major histocompatibility complex class-I
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Protocol [1] Each cell line is studied in growth inhibition experiments using 96-well microtiter plates
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