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[6] [36] It was serendipitously discovered in 1969 that amantadine possesses central dopaminergic stimulant-like properties, [37] [38] and subsequent investigation revealed that rimantadine and adapromine also possess such properties

The relationship of permeability to octanol-water partition coefficient and molecular weight was found to be predictable for drugs with molecular weights less than 400 daltons

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