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I ask: "what specifically is it about such activities that impact testosterone and estrogen?"

Regarding the repurposing of drugs for SCA3 that have positive preclinical data, caffeine likely has a benign course with chronic administration, but can eventually lose effect due to desensitization as previously reported [267]

The homocysteine (Hcy) dependent trans-sulfuration pathway is responsible for maintenance of the intracellular glutathione pool and regulation of this pathway under oxidative stress (Fig 1)

If you choose to drink occasionally, keep consumption minimal and infrequent

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