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2008 Jan;6(1):304

Asphaltenes are a class of macromolecules indigenous to crude oil known to be the primary cause of such clogging due to their tendency to aggregate

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While menstrual irregularities were not systematically reported as adverse events in published results, the substantial weight loss achieved (approximately 20.9% with the 15 mg dose) would be expected to influence reproductive hormone dynamics in premenopausal women based on established weight loss physiology