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Eli Lilly subsequently attempted to patent this as their discovery but it was rejected in court due to the prior publication by Bloom's group (Bloom email)

doi: 10.1093/cdn/nzaa103/5855489 3 Arbones-MainarJ

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Only one study suggests that the peptide may upregulate the receptors of the human growth hormone (hGH), particularly in tendon fibroblasts

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SCFAs like butyrate, which are generated through probiotic fermentation of dietary fiber, inhibit HDACs, leading to epigenetic silencing of pro-inflammatory cytokines (e.g., IL-1, TNF-) by downregulating NF-B and upregulating IL-10 by activating STAT3 (98, 102, 103)