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METHODS Data source This study uses publicly available youth and adult data from Wave 2 (20142015), Wave 3 (20152016), Wave 4 (20162017), and Wave 5 (20182019) of the PATH Study 25 , a large, US nationally representative, cohort study designed to collect information about use of various tobacco products including cigarettes and ENDS, tobacco dependence, cessation, perceptions of risk and harm, overall physical and mental health, peer and family influences, other substance use, and demographic information 25,26

The disruption of the epithelial layers recruits other immune cells such as macrophages and lymphocytes into lung tissue leading to airway inflammation

The body wants to heal

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Save copies of correspondence, and make a habit of reviewing session histories