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Hepatic expression of ADH5, an enzyme responsible for intracellular formaldehyde detoxification [19,52], were lower after AA exposure in the Aldh2*2 KI homozygous mice than in the WT mice, despite the persistent increase in the plasma formaldehyde (Fig

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10.3389/fcell.2022.931493 131

While GHRP-6 activates GHS-R1a broadly across multiple tissue types with varying downstream consequences, ipamorelin's interaction with the receptor appears to favor the conformational state that drives somatotroph GH release without efficiently engaging the receptor conformations responsible for appetite stimulation or ACTH release