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As noted in the NIAAA Directors Report on Institute Activities to the 136th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism (2014), excessive alcohol consumption has the potential to adversely affect multiple organ systems including the liver, brain, heart, pancreas, lung, kidney, endocrine and immune systems, as well as bone and skeletal muscle. And while it may start with an occasional drink to relax or unwind, repeated exposure to alcohol can rewire your brains reward system, making it harder for you to stop, even when negative effects start to appear