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She updated that review for the World Health Organization in 2015, stepping up the warning by concluding: "Even though no firm conclusions can be drawn on the safety of e-cigarettes, there is an increasing body of evidence indicating harm." "I felt a great responsibility on drawing these conclusions," she said

"Because flow-mediated dilation was impaired by whole smoke, gas phase components of smoke, and plain carbon particles, with no single constituent uniquely responsible, we then explored whether the mechanism involved a common irritation response from the airway involving the vagus nerve," Springer said

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The researchers found a total of 0.23 particles per gram of tissue in the upper lungs, 0.33 in the middle, and 1.65 in the lower lungs

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