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The fundamental process might entail that Rg3 enforced SOX2 expression and exerted cytotoxic effects due to the downregulation of SOX2 in AGS/DDP GC cells, resulting in inhibiting downstream PI3K/Akt signaling pathway hyperactivation (113)

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Ferroptosis, coined by Stockwell's group in 2012, designates a specific non-apoptotic cell death caused by such accumulation of lipid peroxides following cystine deprivation (42)

Ongoing research is expected to expand the list of TCM-derived metabolites with evidence-based benefits, to optimize their formulations (for example, improving bioavailability of poorly absorbed molecules), and to clarify their roles in practice (whether as adjuncts to standard therapy to address residual risks like inflammation, or as alternatives in specific scenarios such as statin-intolerant patients)

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BPC-157 is prohibited by the World Anti-Doping Agency under Section S0: Non-Approved Substances