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Investigations have shown that xCT expression is increased in both the spinal cord of ALS patients and isolated microglia of mutant superoxide dismutase 1 (SOD1) ALS animals

Hinson JA, Monks TJ, Hong M, Highet RJ, Pohl LR

This isn't strictly necessary for safety, but it can help some people avoid any minor digestive sensitivity when starting a new routine

Ondrejickova O, Ziegelhoeffer A, Gabauer I, Sotnikova R, Styk J, Gibala P, et al

It requires specific instruments and tiny cuts

Given the heterogenic nature of NAFLD, targeting metabolic, anti-inflammatory, or anti-fibrotic disease pathways simultaneously may exert an additive or synergistic effect and combination therapy may prove to be a an important tool in the future development of pharmacological treatment options