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Composition Active Agent: Benzyl Alcohol 0.9% (bacteriostatic preservative) Base: Sterile Water Volume: 10ml or 30ml per vial (select above) pH: 4.57.0 Container: Sealed glass vial with rubber septum and aluminium crimp cap Manufactured in: Boecillo (Valladolid), Spain ISO 13485:2016 + GMP + ISO 9001:2016 certified facility Intended use: Research Use Only (RUO) not for clinical use In-use period: Up to 28 days after first puncture with aseptic technique Storage Store unopened vials at room temperature (15-25C)

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MTHFR stands for methylenetetrahydrofolate reductase

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In in-vivo studies using the IMQ-induced PsO model, treatment with the NLC-based ointment significantly reduced the spleen index and levels of TNF-, IL-6, and IL-17