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Conflict of interest The authors declare that they have known competing financial interests or personal relationships that could have appeared to influence the work reported in this manuscript

Label with date after first puncture and store as specified below

A high-glucose environment temporarily enhances alkaline phosphatase (ALP) activity but reduces mineralization capacity, decreases the expression of Runt-related transcription factor 2 (Runx2), type I collagen, and osteocalcin, while upregulating adipogenic genes such as PPAR- (39)

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