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Remarkably, a study by Escribano et al revealed that, when compared with the control group, children with severe AATD showed significantly increased levels of oxidative stress biomarkers and decreased levels of antioxidants, as expressed by lower total and reduced glutathione levels, decreased catalase activity, and increased glutathione peroxidase activity

Concentration = 10mg 2mL = 5mg/mL If a protocol step calls for 2mg, the injection volume is: 2mg 5mg/mL = 0.4mL On a standard U-100 insulin syringe (where 100 units = 1mL), 0.4mL converts to 40 units

For long-term storage, keep at -20C

The most common side effects reported in trials include mild to moderate gastrointestinal issues: nausea, diarrhea, vomiting, and constipation

Normal levels of GSH have been shown to have roles in restricting serine availability to preserve regulatory T cell (Treg) functionality (Kurniawan et al., 2020)

Handling and Storage Recommendations Keep lyophilized vials sealed at 20C or colder, dry, and protected from light