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10.1196/annals.1297.059 Ann N Y Acad Sci

The charged nature of GSH (negative at physiological pH) suggests that GSH cannot passively diffuse into the mitochondria, because the mitochondrial matrix has a negative potential relative to the cytoplasm

The other numerous skin lightening methods that would be preferred by most dermatologists over IV drips are due to them being safer and much more effective than many of those methods