Furthermore, in a randomized, double-blind, placebo-controlled study enrolling 70 patients with AD aged 6 to 12 years, the administration of melatonin (6 mg daily) demonstrated to improve SCORAD ( p = 0.007), objective SCORAD ( p = 0.001), serum total IgE levels ( p = 0.005) and Childrens Sleep Habits Questionnaire scores ( p = 0.006) at 6 weeks (40)
The hinge region is important for nuclear localization and contains a bipartite nuclear localization signal
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Cent Nerv Syst Agents Med Chem 10:287297 Mahadevan D, Von Hoff DD (2007) Tumor-stroma interactions in pancreatic ductal adenocarcinoma