When you take Vitamin B12 through an intramuscular injection, you can process 100% of that vitamin, whereas with an oral supplement, usually only about 50-70% of the vitamin is able to be processed and metabolized
BioMed Research International 2021:9924314
Increases cellular NAD and SAM availability and lowers intracellular 1-MNA, consistent with enhanced NAD salvage and a favorable methyl economy [13]
The major difference between a B12 shot and an oral supplement is that the B12 shots or injectables are directly put into the bloodstream while the oral ones take time to ingest through the bodys digestive system
Supplements and foods reinforced with this vitamin contain B12 in its free form, which makes it more readily available for absorption in your system
Higher NAD is associated with SIRT1 activity, studied in relation to cellular repair, stress response, and aging pathways