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4 Gut microbiota dysbiosis and abnormal activation of the innate immune system 4.1 Evidence for the association between complement components and schizophrenia Current studies have identified elevated transcript levels of complement components (C1qA, C3, C4, C5) in patients with schizophrenia (114) (see Table 2 ), suggesting, albeit not entirely consistently, that increased activation of the classical complement pathway may be associated with SZ
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Can J Physiol Pharmacol 100(5):486491 Esposito S, Laino D, DAlonzo R, Mencarelli A, Di Genova L, Fattorusso A, Argentiero A, Mencaroni E (2019) Pediatric sleep disturbances and treatment with melatonin
For PCHs that are unable to attest affirmatively for an element, there are likely to be additional costs associated with activities such as updating hospital policies, engaging senior leadership, participating in new quality improvement activities, performing additional data analysis, and training staff
