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The formation of metal-flavonoid complexes significantly enhances their bioavailability, positioning these compounds as promising candidates for next-generation therapeutics ( Ehretia tinifolia extract (ETME) counteracts this response by activating the protective Nrf2/HO-1 pathway while suppressing NF-B/MAPK-mediated inflammation

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BMC Psychiatry 26 , 341 (2026)

Certain health conditions, such as pernicious anemia or specific gastrointestinal disorders that affect B12 absorption, may require even longer-term or lifelong monthly injections